Evaluating the Effects of Pentoxifylline Administration on Experimental Pressure Sore in Rats by Biomechanical Examinations

Purpose: The aim of the present investigation was to study the effect of pentoxifylline administration on wound healing process of an experimental pressure sore in rat by biomechanical evaluating method.Materials and Methods: In ten adult male rats under general anesthesia and sterile conditions one experimental pressure sore by no20Halsted mosquito forceps were made. A double layer folded skin of dorsal region were held under most pressure grade of the forceps for 2 hours. It was followed by 30 minutes (the skin) relaxation. This procedure was repeated for 12 times during three consecutive days. Seven days later pressure sore was made. Rats were divided into control and experimental groups. Pentoxifylline was injected intraperitonealy at a dose of 50mg/kg daily from beginning of pressure sore for twenty days. After these procedures rats were killed by chloroform, and samples were extracted from the wound and surrounding skin. Samples were biomechanically examined by a material testing instrument and maximum stress (N/mm2) work up to maximum force (Nmm).The young modulus of elasticity (N/mm) were them calculated.Results: In experimental group maximum stress (2.05±0.15) and work up to maximum force (63.75±4.97) were significantly higher than those of control group (1.3±0.27) and (43.3±14.96) (p=0.002 and p=0.035 relatively).Conclusion: Pentoxifylline administration in rats which had an experimental pressure sore significantly accelerated wound healing process compared to those of control group which was observed by biomechanical examination.